N-Aryl Amino Acids as Potential Antibacterial Agents

The resistance of bacteria to current antibiotic drugs and the re-occurrence different ailments after several therapeutic protocols continue be a cause for concern. Arylated amino acids are vital synthons many compounds; they serve as essential building blocks in synthesis nitrogen heterocycles with various biological activities. This research reports on some N-aryl evaluates their antibacterial 3a–3j were obtained by reacting 4-substituted fluorobenzene 1a–1d 2a–2g via metal-free base-induced aryl amination reaction halides. activities synthesized compounds evaluated against eight bacterial strains (Four Gram-positive, Bacillus subtilis (ATCC 6633), Streptococcus pneumonia 33400), Staphylococcus aureus 25923), epidermidis 14990), four Gram-negative, Enterobacter cloacae 43560), Escherichia coli 25922), Proteus mirabilis 43071), Klebsiella oxytoca 13182) using agar well diffusion method streptomycin reference drug. screening indicates that 3a, 3e, 3j have promising broad-spectrum potential, acid displayed activity was comparable standard drug pneumonia, coli, mirabilis.